After finishing his training as a cabinetmaker from Ludvig Pontoppidan in 1952, Gjerløv-Knudsen studied furniture design in the Danish School of Arts and Crafts and architecture in The Royal Danish Academy of Fine Arts in 1955.
In the 1960’s Gjerløv designed the OGK Safari chair and daybed for Skovsheds Møbelfabrik and the Moduline collection for France & Sons together with Torben Lind, from which the armchair is the most known.
Gjerløv-Knudsen and Lind also worked together on the iconic Skopa chair for IKEA in 1972, made of propene in orange, brown or white with a corduroy fabric pillow.
Ole Gjerløv-Knudsen also worked as a teacher at the Danish School of Arts and Crafts from 1962-90 where he also acted as the principal for the department of furniture design.